Instrumentation

Human Genomics and Genetic Analysis Laboratory Core Instrumentation

GENETIC ANALYSIS (STR, SNP, AND SEQUENCING)

INSTRUMENTATION

ABI 3130xl Genetic Analyzer
ABI 3500xl Genetic Analyzer
ABI Open Array Platform with AccuFill system
ABI 7500 and 7900 HT Real-Time PCR Systems
Hamilton Starlet and Nimbus Platforms
Tecan EVO 150

IDENTITY TESTING METHODS

Promega Powerplex Y23, Fusion 5C and 6C,
ABI Identifiler Plus, Globalfiler, and Yfiler
Taqman SNP identification
Qiagen Investigator QS

ANCESTRY TESTING METHODS

Sorenson WorldWide Ancestry^TM autosomal SNP detection (geographic affiliation)

PAPERS AND PUBLICATIONS

Mitochondrial DNA and Y-chromosome haplogroup: 14 peer-reviewed publications were reviewed and a database developed of 109 different populations being evaluated for their proportional makeup from any of 18 primary Y-haplogroups.

ESTIMATING GENETIC ANCESTRY

Industries where there is potential that a product may have variable effects depending on an individual’s genetic ancestry can greatly benefit from the ability to qualitatively stratify study participants.

AN ADMIXTURE SIMULATION PROGRAM

Validating genetic ancestry estimation systems. A key area of interest in studying population genetics is detection and estimation of genetic admixture in offspring from parents with mixed ancestry.